Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description of the disease and genetics.

@article{Morris1982LysosomeLS,
  title={Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description of the disease and genetics.},
  author={M. D. Morris and C Bhuvaneswaran and Helen Shio and Stanley Fowler},
  journal={The American journal of pathology},
  year={1982},
  volume={108 2},
  pages={140-9}
}
We describe a strain of BALB/c mice, designated NCTR-BALB/c, carrying a new genetic disorder characterized by excessive tissue deposition of cholesterol and phospholipid. The mice exhibit progressive incoordination, grow less rapidly, and die 80-120 days after birth. In comparison with control animals of the same age, organ weights in the affected animals are lower in absolute value but higher relative to body weight, except for the thymus, which is atrophied, and for the lung and testes, whose… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Telocytes: a potential defender in the spleen of Npc1 mutant mice

Journal of cellular and molecular medicine • 2017

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2015
View 2 Excerpts

Similar Papers

Loading similar papers…