Lysosome-like compartments of Trypanosoma cruzi trypomastigotes may originate directly from epimastigote reservosomes

@article{Vidal2017LysosomelikeCO,
  title={Lysosome-like compartments of Trypanosoma cruzi trypomastigotes may originate directly from epimastigote reservosomes},
  author={Juliana C Vidal and Carolina de Lima Alcantara and Wanderley de Souza and Narcisa L Cunha-E-Silva},
  journal={Parasitology},
  year={2017},
  volume={144},
  pages={841 - 850}
}
SUMMARY Trypanosoma cruzi epimastigote reservosomes store nutrients taken up during the intense endocytic activity exhibited by this developmental form. Reservosomes were classified as pre-lysosomal compartments. In contrast, trypomastigote forms are not able to take up nutrients from the medium. Interestingly, trypomastigotes also have acidic organelles with the same proteases contained in epimastigote reservosomes. Nevertheless, the origin and function of these organelles have not been… 
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Tridimensional Electron Microscopy Analysis of the Early Endosomes and Endocytic Traffic in Trypanosoma cruzi Epimastigotes.
The Functional Characterization of TcMyoF Implicates a Family of Cytostome-Cytopharynx Targeted Myosins as Integral to the Endocytic Machinery of Trypanosoma cruzi
TLDR
A potential mechanism used by the SPC to drive the inward flow of material for digestion is highlighted and unveils a new level of overlapping complexity in this system with four distinct myosin isoforms targeted to this feeding structure.
Knockout of the gamma subunit of the AP-1 adaptor complex in the human parasite Trypanosoma cruzi impairs infectivity and differentiation and prevents the maturation and targeting of the major protease cruzipain
TLDR
The defective processing and transport of cruzipain upon AP-1 ablation may underlie the phenotype of TcγKO parasites, which has significantly reduced infectivity towards mammalian cells.
An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi
TLDR
An intracellular ammonium transporter of T. cruzi (TcAMT) that localizes to acidic compartments and is important for replication, differentiation, and resistance to starvation and osmotic stress is identified.
The effects of endoplasmic reticulum stressors, tunicamycin and dithiothreitol on Trypanosoma cruzi.

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