Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

@article{Saftig2009LysosomeBA,
  title={Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function},
  author={P. Saftig and J. Klumperman},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={623-635}
}
Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade extracellular material that has been internalized by endocytosis and intracellular components that have been sequestered by autophagy. In addition, specialized cells contain lysosome-related organelles that store and secrete proteins for cell-type-specific functions. The functioning of a healthy cell is dependent on the proper targeting of newly synthesized lysosomal proteins. Accumulating evidence suggests that… Expand
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