Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins

  title={Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins},
  author={Steven M. Banik and Kayvon Pedram and Simon P. Wisnovsky and Nicholas M. Riley and Carolyn R. Bertozzi},
Targeted protein degradation is a powerful strategy to address the canonically undruggable proteome. However, current technologies are limited to targets with cytosolically-accessible and ligandable domains. Here, we designed and synthesized conjugates capable of binding both a cell surface lysosome targeting receptor and the extracellular domain of a target protein. These lysosome targeting chimeras (LYTACs) consist of an antibody fused to agonist glycopeptide ligands for the cation… 

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