Lysosomal-type PLA2 and turnover of alveolar DPPC.

@article{Fisher2001LysosomaltypePA,
  title={Lysosomal-type PLA2 and turnover of alveolar DPPC.},
  author={Aron B. Fisher and Chandra Dodia},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 4},
  pages={
          L748-54
        }
}
This study evaluated the role of a lysosomal-type phospholipase A2 (aiPLA(2)) in the degradation of internalized dipalmitoylphosphatidylcholine (DPPC) and in phospholipid synthesis by the rat lung. Uptake and degradation of DPPC were measured in isolated perfused rat lungs over 3 h following endotracheal instillation of [(3)H]DPPC in mixed unilamellar liposomes plus or minus MJ33, a specific inhibitor of lung aiPLA(2). Uptake of DPPC was calculated from total tissue-associated radiolabel, and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2003
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND

Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.

  • Archives of biochemistry and biophysics
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Surfactant catabolism and recycling. In: Lung Surfactant: Clearance and Cellular Processing, edited by Rooney SA

AB Fisher
  • Austin, TX: Landes Bioscience,
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Lysosomes from rabbit type II cells catabolize surfactant lipids.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Characterization of acidic Ca(2+)-independent phospholipase A2 of bovine lung.

  • Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 1998
VIEW 4 EXCERPTS

Diversity of group types, regulation, and function of phospholipase A2.

  • The Journal of biological chemistry
  • 1994
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL