Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.

@article{Autefage2009LysosomalSP,
  title={Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.},
  author={H{\'e}l{\`e}ne Autefage and Virginie Albinet and Virginie Garcia and Hortense Berg{\`e}s and Marie-Laure Nicolau and Nicole Therville and Marie-Françoise Alti{\'e} and Catherine Caillaud and Thierry Levade and Nathalie Andrieu-Abadie},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 17},
  pages={
          11507-16
        }
}
Apoptosis is a highly organized, energy-dependent program by which multicellular organisms eliminate damaged, superfluous, and potentially harmful cells. Although caspases are the most prominent group of proteases involved in the apoptotic process, the role of lysosomes has only recently been unmasked. This study investigated the role of the lysosomal serine protease CLN2 in apoptosis. We report that cells isolated from patients affected with late infantile neuronal ceroid lipofuscinosis (LINCL… CONTINUE READING

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