Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.

@article{Bernstein1992LysosomalPA,
  title={Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.},
  author={H. G. Bernstein and Heidrun Kirschke and Bernd Wiederanders and Rudolph M. Khudoerkov and Wolfgang Hinz and Ari Rinne},
  journal={Acta histochemica. Supplementband},
  year={1992},
  volume={42},
  pages={19-24}
}
The cathepsin B, D and L were studied by immunohistochemical techniques in the human postmortem brain. The enzyme were primarily localized in neurons. Makroglial cells were seldom immunostained. It is shown that cathepsins B and D frequently occur in neuritic plaques of Alzheimer victims, thereby raising the question, whether or not cathepsin immunohistochemistry is a useful tool in the diagnosis of this disease. Furthermore, we identified certain glial cells to be immunoreactive for cathepsins… CONTINUE READING