Lysosomal processing of progranulin

  title={Lysosomal processing of progranulin},
  author={Xiaolai Zhou and Daniel H. Paushter and Tuancheng Feng and Lirong Sun and Thomas Reinheckel and Fenghua Hu},
  booktitle={Molecular Neurodegeneration},
Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism of PGRN in the lysosome is still unclear. Here, we report that PGRN is processed into ~10 kDa peptides intracellularly in multiple cell types and tissues and this processing is dependent on lysosomal activities… CONTINUE READING
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