Lysosomal-mediated degradation of apoptotic thymocytes within thymic nurse cells.

  title={Lysosomal-mediated degradation of apoptotic thymocytes within thymic nurse cells.},
  author={Michael D. Samms and Deborah Philp and F Emanus and Obi U Osuji and Mark Pezzano and Jerry Charles Guyden},
  journal={Cellular immunology},
  volume={197 2},
A thymic epithelial cell line (tsTNC-1) that maintains the ability to selectively bind and internalize immature alphabetaTCR(lo)CD4(+)CD8(+) thymocytes in vitro was used in long-term coincubation experiments to determine the ultimate fate of thymocytes that remained within intracytoplasmic vacuoles of thymic nurse cells (TNCs). In an earlier report, a subset of the population released from the TNC interaction was shown to mature to the alphabetaTCR(hi)CD69(hi) stage of development, while… CONTINUE READING

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