Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.

@article{Venkatachalam2006LysosomalLO,
  title={Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.},
  author={Kartik Venkatachalam and Thomas Hofmann and Craig T. Montell},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 25},
  pages={17517-27}
}
Mucolipidosis type IV is an autosomal recessive lysosomal storage disorder characterized by severe neurodegeneration, achlorhydria, and visual impairments such as corneal opacity and strabismus. The disease arises due to mutations in a group 2 transient receptor potential (TRP)-related cation channel, TRPML1. Mammals encode two additional TRPML proteins named TRPML2 and TRPML3. Information regarding the propensity of these proteins to multimerize, their subcellular distribution and mechanisms… CONTINUE READING
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