Lysosomal glycogen storage mimicking the cytological picture of Pompe's disease as induced in rats by injection of an alpha-glucosidase inhibitor. I. Alterations in liver.

@article{LllmannRauch1981LysosomalGS,
  title={Lysosomal glycogen storage mimicking the cytological picture of Pompe's disease as induced in rats by injection of an alpha-glucosidase inhibitor. I. Alterations in liver.},
  author={Renate L{\"u}llmann-Rauch},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  year={1981},
  volume={38 1},
  pages={89-100}
}
The present paper describes an animal model of lysosomal glycogenosis as induced by a competitive inhibitor of alpha-glucosidase. Rats received intraperitoneal injections of the inhibitor, a pseudotetrasaccharide (Acarbose, Bay g 5421); liver tissue was examined by light and electron microscopy. Substrate-histochemical and enzyme-cytochemical methods were… CONTINUE READING