Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis.

@article{Zhao2003LysosomalEP,
  title={Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis.},
  author={M. Zhao and F. Antunes and J. Eaton and U. Brunk},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 18},
  pages={
          3778-86
        }
}
Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal rupture followed by apoptosis or necrosis. Enhanced intracellular production of reactive oxygen species (ROS), presumably of mitochondrial origin, is also observed when cells are exposed to nonoxidant pro-apoptotic agonists of cell death. We hypothesized that ROS generation in this latter case might promote the apoptotic cascade and could arise from effects of released lysosomal materials on mitochondria… Expand
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Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy.
TLDR
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