Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes.

@article{Claus1998LysosomalET,
  title={Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes.},
  author={Volker Claus and Andrea Jahraus and Torunn Elisabeth Tjelle and Trond Berg and Heidrun Kirschke and Heinz Faulstich and Gareth Griffiths},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 16},
  pages={9842-51}
}
In this study we take advantage of recently developed methods using J774 macrophages to prepare enriched fractions of early endosomes, late endosomes, dense lysosomes, as well as phagosomes of different ages enclosing 1-micron latex beads to investigate the steady state distribution and trafficking of lysosomal enzyme activity between these organelles. At steady state these cells appear to possess four different cellular structures, in addition to phagolysosomes, where acid hydrolases were… CONTINUE READING

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