Lysosomal cysteine proteases in atherosclerosis.

  title={Lysosomal cysteine proteases in atherosclerosis.},
  author={Jianwen Liu and Galina K Sukhova and Jiu-Song Sun and Weihua Xu and P. Scott Libby and G P Shi},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 8},
Atherosclerosis is an inflammatory disease characterized by extensive remodeling of the extracellular matrix architecture of the arterial wall. Although matrix metalloproteinases and serine proteases participate in these pathologic events, recent data from atherosclerotic patients and animals suggest the participation of lysosomal cysteine proteases in atherogenesis. Atherosclerotic lesions in humans overexpress the elastolytic and collagenolytic cathepsins S, K, and L but show relatively… CONTINUE READING


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SM Day, JL Reeve, +3 authors W. Fay
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