Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus.

@article{Takematsu1999LysosomalAC,
  title={Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus.},
  author={Hiromu Takematsu and Sandra D{\'i}az and Andrew J. Stoddart and Yan Zhang and Ajit Varki},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 36},
  pages={25623-31}
}
9-O-Acetylation is one of the most common modifications of sialic acids, and it can affect several sialic acid-mediated recognition phenomena. We previously reported a cDNA encoding a lysosomal sialic acid-specific 9-O-acetylesterase, which traverses the endoplasmic reticulum-Golgi pathway and localizes primarily to lysosomes and endosomes. In this study, we report a variant cDNA derived from the same gene that contains a different 5' region. This cDNA has a putative open reading frame lacking… CONTINUE READING

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