Lysosomal acid phosphatase is internalized via clathrin-coated pits.

  title={Lysosomal acid phosphatase is internalized via clathrin-coated pits.},
  author={Annette Hille and Judith Klumperman and Hans J. Geuze and Christopher G. Peters and Frances M. Brodsky and Kurt von Figura},
  journal={European journal of cell biology},
  volume={59 1},
The presence of lysosomal acid phosphatase (LAP) in coated pits at the plasma membrane was investigated by immunocytochemistry in thymidine kinase negative mouse L-cells (Ltk-) and baby hamster kidney (BHK) cells overexpressing human LAP (Ltk-LAP and BHK-LAP cells). Double immunogold labeling showed that at various stages of invaginating coated pits LAP colocalized with clathrin and plasma membrane adaptors (HA-2 adaptors). Quantitation of the immunogold label showed similar density of wild… CONTINUE READING
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