Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

  title={Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo},
  author={Vikram Khurana and Ilan Elson-Schwab and Tudor A. Fulga and Katherine A. Sharp and Carin A Loewen and Erin E. Mulkearns and Jaana Tyynel{\"a} and Clemens R Scherzer and Mel B. Feany},
  booktitle={PLoS genetics},
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detrimental influences. We sought to clarify and molecularly define the connection in vivo in a genetically tractable model organism. Cathepsin D is upregulated with age in a Drosophila model of Alzheimer's disease… CONTINUE READING
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