Lysosomal (vacuolar) proteinases of yeast are essential catalysts for protein degradation, differentiation, and cell survival.

@article{Teichert1989LysosomalP,
  title={Lysosomal (vacuolar) proteinases of yeast are essential catalysts for protein degradation, differentiation, and cell survival.},
  author={U Teichert and B Mechler and Hanne -Lene M{\"u}ller and Dieter H. Wolf},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 27},
  pages={16037-45}
}
Mutants deficient in the vacuolar (lysosomal) endopeptidases proteinase yscA and proteinase yscB of the yeast Saccharomyces cerevisiae exhibit a drastically reduced protein degradation rate under nutritional stress conditions. The differentiation process of sporulation is considerably disturbed by the absence of the two endopeptidases. Also under vegetative growth conditions and under conditions of false protein synthesis, the two vacuolar endopeptidases exhibit some effect on protein… CONTINUE READING
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