Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation.

  title={Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation.},
  author={Micha{\"e}l Monet and Dimitra G Gkika and V'yacheslav Lehen'kyi and Albin Pourtier and Fabien Vanden Abeele and Gabriel Bidaux and V{\'e}ronique Juvin and François A. Rassendren and Sandrine Humez and Natalia Prevarsakaya},
  journal={Biochimica et biophysica acta},
  volume={1793 3},
The physiological role, the mechanisms of activation, as well as the endogenous regulators for the non-selective cationic channel TRPV2 are not known so far. In the present work we report that endogenous lysophospholipids such as lysophosphatidylcholine (LPC) and lysophosphatidylinositol (LPI) induce a calcium influx via TRPV2 channel. This activation is dependent on the length of the side-chain and the nature of the lysophospholipid head-group. TRPV2-mediated calcium uptake stimulated by LPC… CONTINUE READING