Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells.

@article{Pan2007LysophospholipidsRE,
  title={Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells.},
  author={Chien-Yuan Pan and Adonis Zhi-Yang Wu and Yit-Tsong Chen},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 3},
  pages={
          944-56
        }
}
Bioactive lysophospholipids (LPLs) are released by blood cells and can modulate many cellular activities such as angiogenesis and cell survival. In this study, the effects of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) on excitability and exocytosis in bovine chromaffin cells were investigated using the whole-cell configuration of the patch-clamp. Voltage-gated Ca(2+) current was inhibited by S1P and LPA pre-treatment in a concentration-dependent manner with IC(50)s of 0.46… CONTINUE READING

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