Lysophospholipids--Receptor Revelations

@article{Hla2001LysophospholipidsReceptorR,
  title={Lysophospholipids--Receptor Revelations},
  author={Timothy Hla and Menq Jer Lee and Nicolas Ancellin and Jihye Paik and Michael J. Kluk},
  journal={Science},
  year={2001},
  volume={294},
  pages={1875 - 1878}
}
Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these lipid… 

Role of Lysophospholipids in Cell Growth and Survival

Evidence is accumulating that most cellular responses to LPA and S1P are mediated through activation of their cognate G protein-coupled receptors (GPCR), which allow activation of a variety of signal transduction pathways that are integrated to trigger diverse cellular responses.

Modulators of lysophosphatidic acid signalling

Based on the action of LPA on molecular targets in different human pathologies, both receptor-selective agonists and antagonists are sought as potential clinical agents.

Sphingosine-1-phosphate: an enigmatic signalling lipid

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P

The emerging role of lysophosphatidic acid in cancer

Mechanisms by which LPA production or action could be modulated for cancer therapy are indicated.

Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease.

This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.

Sphingosine-1-Phosphate and the Regulation of Immune Cell Trafficking

Pharmacological and genetic experiments have clearly established the SIP-SIP receptor system as a dominant regulatory axis for the trafficking of lymphocytes and Manipulating this regulatory axis might lead to the development of therapies that target immune system dysfunctions.

Sphingosine 1-phosphate as a novel immune regulator of dendritic cells

The role played by S1P on the DC system and its effects in immune-related pathological states are focused on.

Regulation of macrophage function by sphingosine-1-phosphate.

...

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