Lysophospholipids--Receptor Revelations

@article{Hla2001LysophospholipidsReceptorR,
  title={Lysophospholipids--Receptor Revelations},
  author={Timothy Hla and Menq Jer Lee and Nicolas Ancellin and Jihye Paik and Michael J. Kluk},
  journal={Science},
  year={2001},
  volume={294},
  pages={1875 - 1878}
}
Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these lipid… 
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The role played by S1P on the DC system and its effects in immune-related pathological states are focused on.
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