Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.

@article{LpezSagaseta2012LysophospholipidPB,
  title={Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.},
  author={Jacinto L{\'o}pez-Sagaseta and Leah V Sibener and Jennifer E. Kung and Jenny E Gumperz and Erin J. Adams},
  journal={The EMBO journal},
  year={2012},
  volume={31 8},
  pages={2047-59}
}
Invariant Natural Killer T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies of lysophosphatidylcholine (LPC) presentation by human CD1d and its recognition by a native, LPC-specific iNKT TCR. Human CD1d presenting LPC adopts an altered conformation from that of CD1d presenting glycolipid antigens, with a shifted α1 helix resulting in an open A' pocket. Binding of the iNKT TCR requires a 7… CONTINUE READING

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