Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.

@article{Nishina2006LysophosphatidylethanolamineIG,
  title={Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.},
  author={Atsuyoshi Nishina and Hirokazu Kimura and Akihiro Sekiguchi and Ryo-hei Fukumoto and Satoshi Nakajima and Shoei Furukawa},
  journal={Journal of lipid research},
  year={2006},
  volume={47 7},
  pages={1434-43}
}
We found that Grifola frondosa extracts induced the activation of mitogen-activated protein kinase (MAPK) in cultured PC12 cells, a line of rat pheochromocytoma cells. The active substance was isolated by a few chromatographic steps, including high-performance liquid chromatography, and was identified to be lysophosphatidylethanolamine (LPE) from various structural analyses. LPE from G. frondosa (GLPE) was confirmed to induce the activation of MAPK of cultured PC12 cells and was found to… CONTINUE READING
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