Lysophosphatidylcholine transduces Ca2+ signaling via the platelet-activating factor receptor in macrophages.

@article{Ogita1997LysophosphatidylcholineTC,
  title={Lysophosphatidylcholine transduces Ca2+ signaling via the platelet-activating factor receptor in macrophages.},
  author={Teruhiko Ogita and Yoshihiko Tanaka and Takashi Nakaoka and Rumiko Matsuoka and Yukimi Kira and Makiko Nakamura and Takeshi Shimizu and Toshiro Fujita},
  journal={The American journal of physiology},
  year={1997},
  volume={272 1 Pt 2},
  pages={H17-24}
}
To clarify the molecular mechanism underlying the lysophosphatidylcholine (LPC) signaling, we studied the effect of LPC on the intracellular free calcium concentration ([Ca2+]i) in murine peritoneal macrophages. LPC when added alone induced biphasic elevation of [Ca2+]i, which consisted of a rapid increase followed by sustained elevation. LPC, when added with equimolar cholesterol, induced only the rapid increase in [Ca2+]i, which was blocked by WEB-2086, a selective platelet-activating factor… CONTINUE READING
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