Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature.

  title={Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature.},
  author={R. Scalia and T. Murohara and B. Campbell and A. Kaji and A. Lefer},
  journal={The American journal of physiology},
  volume={272 6 Pt 2},
Synthetic exogenous lysophosphatidylcholine (LPC) was used to induce leukocyte-endothelial cell interaction, utilizing intravital microscopy in the rat mesenteric microvasculature. Superfusion of the rat mesentery with 10 microM LPC significantly and time dependently increased leukocyte rolling and adherence compared with control rats. Moreover, LPC superfusion did not alter systemic blood pressure or mesenteric venular shear rate. Administration of either an anti-P-selectin monoclonal antibody… Expand
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