Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism.

Abstract

IL-1beta released from activated macrophages contributes significantly to tissue damage in inflammatory, degenerative, and autoimmune diseases. In the present study, we identified a novel mechanism of IL-1beta release from activated microglia (brain macrophages) that occurred independently of P2X(7) ATP receptor activation. Stimulation of LPS-preactivated… (More)

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