Lysophosphatidylcholine reversibly arrests exocytosis and viral fusion at a stage between triggering and membrane merger.

@article{Vogel1993LysophosphatidylcholineRA,
  title={Lysophosphatidylcholine reversibly arrests exocytosis and viral fusion at a stage between triggering and membrane merger.},
  author={Steven S. Vogel and Eugenia Leikina and Leonid V. Chernomordik},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 34},
  pages={25764-8}
}
Little is known of the events occurring between membrane fusion triggering and subsequent fusion steps. To dissect this process we applied a reversible inhibitor of membrane fusion, lysophosphatidylcholine, to arrest exocytosis and virus-mediated syncytia formation. Next Ca2+ or H+ (the respective fusion triggers) was administered and later removed. Then, inhibitor was withdrawn and fusion ensued, demonstrating that triggering causes the formation of an "activated state," which later develops… CONTINUE READING

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