Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum

@article{Brancucci2017LysophosphatidylcholineRS,
  title={Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum},
  author={Nicolas M. B. Brancucci and J. P. Gerdt and Chengqi Wang and Mariana De Niz and N. Philip and S. Adapa and M. Zhang and Eva Hitz and I. Niederwieser and Sylwia D. Boltryk and Marie-Claude N. Laffitte and M. Clark and Christof Gr{\"u}ring and Deepali Ravel and Alexandra Blancke Soares and Allison R. Demas and S. Bopp and Bel{\'e}n Rubio-Ruiz and A. Conejo-Garc{\'i}a and D. Wirth and E. Gendaszewska-Darmach and M. Duraisingh and John H. Adams and T. Voss and A. Waters and R. Jiang and J. Clardy and M. Marti},
  journal={Cell},
  year={2017},
  volume={171},
  pages={1532 - 1544.e15}
}
Summary Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective to the mosquito vector. Gametocyte production rates vary depending on environmental conditions, but external stimuli remain obscure. Here, we show that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P… Expand
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation
Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites.
Metabolic regulation of sexual commitment in Plasmodium falciparum.
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