Corpus ID: 92441019

Lysophosphatidylcholine Inhibits Endothelial Cell Migration and Proliferation via Inhibition of the Extracellular Signal–Regulated Kinase Pathway

@article{YoshiyukiRikitake2000LysophosphatidylcholineI,
  title={Lysophosphatidylcholine Inhibits Endothelial Cell Migration and Proliferation via Inhibition of the Extracellular Signal–Regulated Kinase Pathway},
  author={YoshiyukiRikitake and SeinosukeKawashima and TomoyaYamashita and TomomiUeyama and SatoshiIshido and Hakhotta and Ken-ichiHirata and MitsuhiroYokoyama},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2000}
}
Abstract—Lysophosphatidylcholine (lysoPC), a major lipid component of oxidized low density lipoprotein, inhibits endothelial cell (EC) migration and proliferation, which are critical processes during angiogenesis and the repair of injured vessels. However, the mechanism(s) of lysoPC-induced inhibition of EC migration and proliferation has not been clarified. In this report, we demonstrate the critical role of extracellular signal–regulated kinase (ERK) in growth factor–stimulated EC migration… Expand
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