Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum.

@article{Kraichely2009LysophosphatidylCM,
  title={Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum.},
  author={Robert E. Kraichely and Peter R Strege and Michael G Sarr and Michael L. Kendrick and Gianrico Farrugia},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 4},
  pages={
          G833-9
        }
}
The L-type Ca2+ channel expressed in gastrointestinal smooth muscle is mechanosensitive. Direct membrane stretch and shear stress result in increased Ca2+ entry into the cell. The mechanism for mechanosensitivity is not known, and mechanosensitivity is not dependent on an intact cytoskeleton. The aim of this study was to determine whether L-type Ca2+ channel mechanosensitivity is dependent on tension in the lipid bilayer in human jejunal circular layer myocytes. Whole cell currents were… CONTINUE READING

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