Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells.

Abstract

Phospholipase D (PLD) is activated in mammalian cells in response to a variety of growth factors and may play a role in cell proliferation. Lysophosphatidic acid (LPA) is a bioactive metabolite potentially generated as a result of PLD activation. Two human prostate cancer cell lines, PC-3 and LNCaP, express membrane PLD activity. The effects of LPA on PLD… (More)

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@article{Qi1998LysophosphatidicAS, title={Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells.}, author={C. Qi and J. H. Park and Tanya Gibbs and Devon Shirley and C. D. Bradshaw and Krishna M. Ella and K. Eberhard Meier}, journal={Journal of cellular physiology}, year={1998}, volume={174 2}, pages={261-72} }