Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation.

@article{Subramanian2010LysophosphatidicAR,
  title={Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation.},
  author={Pallavi Subramanian and Ela Karshovska and Patricia Reinhard and Remco T. A. Megens and Zhe Zhou and Shamima Akhtar and Uwe Schumann and Xiaofeng Li and Marc A. M. J. van Zandvoort and Christian Ludin and Christian Weber and Andreas Schober},
  journal={Circulation research},
  year={2010},
  volume={107 1},
  pages={96-105}
}
RATIONALE The chemokine CXCL12 (CXC motif ligand 12) and its receptor CXCR 4 (CXC motif receptor 4) direct the recruitment of smooth muscle progenitor cells (SPCs) in neointima formation after vascular injury. Lysophosphatidic acid (LPA) induces CXCL12 and neointimal accumulation of smooth muscle cells (SMCs) in uninjured arteries. Thus, we hypothesize that LPA may regulate CXCL12-mediated vascular remodelling. OBJECTIVES We evaluated the role of LPA receptors in initiating CXCL12-dependent… CONTINUE READING
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