Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure.

@article{Panchatcharam2008LysophosphatidicAR,
  title={Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure.},
  author={Manikandan Panchatcharam and Sumitra Miriyala and Fanmuyi Yang and Mauricio Enrique Mena Rojas and Christopher End and Christopher Vallant and Anping Dong and Kevin Lynch and Jerold Chun and Andrew J. Morris and Susan S Smyth},
  journal={Circulation research},
  year={2008},
  volume={103 6},
  pages={662-70}
}
Phenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMCs, but an endogenous role for this bioactive lipid as a regulator of SMC function in vivo has not been established. Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible for generation of… CONTINUE READING
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Overexpression of autotoxin/ lysophospholipase D reveals a novel path for regulation of hemostasis in mice

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