Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.

@article{Kumar2009LysophosphatidicAR,
  title={Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.},
  author={Sekar Ashok Kumar and Xiaojie Hu and Michelle T Brown and Brenda Kuschak and Tiffany A. Hernandez and James Blain Johnston and Spencer B Gibson},
  journal={Leukemia & lymphoma},
  year={2009},
  volume={50 12},
  pages={2038-48}
}
Lysophosphatidic acid (LPA) protects chronic lymphocytic leukemia (CLL) cells from apoptosis. Vascular endothelial growth factor (VEGF) also protects CLL cells against apoptosis. The mechanism for LPA protection against apoptosis in CLL cells is unknown. Herein, we show CLL cells express LPA receptors LPA(1-5) but in normal B cells, LPA(1) was rarely expressed and LPA(3,) LPA(4,) and LPA(6) were undetectable whereas the other LPA receptors were expressed. LPA plasma levels are similar in… CONTINUE READING