Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G(i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases.

@article{Grey2001LysophosphatidicAI,
  title={Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G(i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases.},
  author={Andrew Grey and Tatjana Banovic and Dorit Naot and Beth L. Hill and Karen E. Callon and Ian R Reid and J. Cornish},
  journal={Endocrinology},
  year={2001},
  volume={142 3},
  pages={1098-106}
}
The simple glycerophospholipid lysophosphatidic acid (LPA) acts both as an intermediary in phospholipid metabolism and as an intercellular signaling molecule in its own right. In various cell types, LPA signals through its membrane-bound, G protein-coupled receptors to influence cellular processes such as proliferation, survival, and cytoskeletal function. Its actions in bone cells have not been studied. Here we show that the LPA receptor, LP(A1)/edg-2/vzg-1, is expressed in primary rat… CONTINUE READING

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