Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action

@article{Berdichevets2010LysophosphatidicAI,
  title={Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action},
  author={Iryna N Berdichevets and Tatiana V Tyazhelova and Kh. R. Shimshilashvili and Evgeny I. Rogaev},
  journal={Biochemistry (Moscow)},
  year={2010},
  volume={75},
  pages={1088-1097}
}
Lysophosphatidic acid (LPA) is a lipid mediator required for maintaining homeostasis of numerous physiological functions and also involved in development of some pathological processes through interactions with G protein-coupled receptors. Recently many data have appeared about the role of this phospholipid in humans, but pathways of LPA biosynthesis and mechanisms of its action remain unclear. This review presents modern concepts about biosynthesis, reception, and biological activity of LPA in… CONTINUE READING