Lysophosphatidic acid-induced calcium mobilization and proliferation in kidney proximal tubular cells.

@article{Dixon1999LysophosphatidicAC,
  title={Lysophosphatidic acid-induced calcium mobilization and proliferation in kidney proximal tubular cells.},
  author={Richard J Dixon and KEN. H. YOUNG and Nigel John Brunskill},
  journal={American journal of physiology. Renal physiology},
  year={1999},
  volume={276 2},
  pages={F191-F198}
}
Patients with proteinuria tend to develop progressive renal disease with proximal tubular cell atrophy and interstitial scarring. It has been suggested that the nephrotoxicity of albuminuric states may be due to the protein molecule itself or by lipids, such as lysophosphatidic acid (LPA), that albumin carries. LPA was found to cause a transient increase in intracytoplasmic free Ca2+([Ca2+]i) in opossum kidney proximal tubule cells (OK) that was maximal at 100 μM LPA and was dose dependent with… CONTINUE READING