Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.

@article{Young2000LysophosphatidicAC,
  title={Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.},
  author={Kenneth W. Young and Martin D Bootman and Deborah R. Channing and Peter Lipp and Peter R. Maycox and John C. Meakin and R. A. John Challiss and Stefan R. Nahorski},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 49},
  pages={
          38532-9
        }
}
Lysophosphatidic acid (LPA)-mediated Ca(2+) mobilization in human SH-SY5Y neuroblastoma cells does not involve either inositol 1,4, 5-trisphosphate (Ins(1,4,5)P(3))- or ryanodine-receptor pathways, but is sensitive to inhibitors of sphingosine kinase. This present study identifies Edg-4 as the receptor subtype involved and investigates the presence of a Ca(2+) signaling cascade based upon the lipid second messenger molecule, sphingosine 1-phosphate. Both LPA and direct G-protein activation… CONTINUE READING
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