Lysophosphatidic acid in atherosclerotic diseases.

  title={Lysophosphatidic acid in atherosclerotic diseases.},
  author={Andreas Schober and Wolfgang Siess},
  journal={British journal of pharmacology},
  volume={167 3},
Lysophosphatidic acid (LPA) is a potent bioactive phospholipid. As many other biological active lipids, LPA is an autacoid: it is formed locally on demand, and it acts locally near its site of synthesis. LPA has a plethora of biological activities on blood cells (platelets, monocytes) and cells of the vessel wall (endothelial cells, smooth muscle cells, macrophages) that are all key players in atherosclerotic and atherothrombotic processes. The specific cellular actions of LPA are determined by… CONTINUE READING
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