Lysophosphatidic acid cooperates with EGF in inducing branching morphogenesis of embryonic mouse salivary epithelium.

@article{Noguchi2006LysophosphatidicAC,
  title={Lysophosphatidic acid cooperates with EGF in inducing branching morphogenesis of embryonic mouse salivary epithelium.},
  author={Yohei Noguchi and Atsushi Okamoto and Takeshi Kasama and Shinobu Imajoh-Ohmi and Takashi Karatsu and Hiroyuki Nogawa},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2006},
  volume={235 2},
  pages={403-10}
}
Epithelial morphogenesis is supported by diffusible growth factors and by nondiffusible cell substrata, such as laminin and fibronectin. When embedded in a laminin-rich basement-membrane substratum, embryonic mouse submandibular epithelium undergoes cell proliferation and branching morphogenesis in response to epidermal growth factor (EGF) in mesenchyme-free culture but not in serum-free medium. In this study, we sought to identify the biologically active factor in serum. As this factor was… CONTINUE READING