Lysophosphatidic acid as a lipid mediator with multiple biological actions.

@article{Aikawa2015LysophosphatidicAA,
  title={Lysophosphatidic acid as a lipid mediator with multiple biological actions.},
  author={Shizu Aikawa and Takafumi Hashimoto and Kuniyuki Kano and Junken Aoki},
  journal={Journal of biochemistry},
  year={2015},
  volume={157 2},
  pages={
          81-9
        }
}
Lysophosphatidic acid (LPA) is one of the simplest glycerophospholipids with one fatty acid chain and a phosphate group as a polar head. Although LPA had been viewed just as a metabolic intermediate in de novo lipid synthetic pathways, it has recently been paid much attention as a lipid mediator. LPA exerts many kinds of cellular processes, such as cell proliferation and smooth muscle contraction, through cognate G protein-coupled receptors. Because lipids are not coded by the genome directly… CONTINUE READING

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