Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.

  title={Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.},
  author={Mu-En Lin and Deron R Herr and Jerold Chun},
  journal={Prostaglandins & other lipid mediators},
  volume={91 3-4},
Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity of the expression pattern and signaling properties of LPA receptors results in multiple influences on developmental, physiological, and… CONTINUE READING