Lysolecithin-lipid interactions in disruption of the canine gastric mucosal barrier.

@article{Duane1986LysolecithinlipidII,
  title={Lysolecithin-lipid interactions in disruption of the canine gastric mucosal barrier.},
  author={William C. Duane and A. P. McHale and Chester E. Sievert},
  journal={The American journal of physiology},
  year={1986},
  volume={250 3 Pt 1},
  pages={G275-9}
}
Lysolecithin has been implicated in the pathogenesis of gastric ulcer and reflux gastritis. By use of canine Heidenhain pouches, we examined effects of lysolecithin on the gastric mucosal barrier both at neutral (PO4 buffer, pH 7) and acidic (0.15 M HCl) pH with respect to interaction of lysolecithin with membrane lipids. At both pH values, 2 mM lysolecithin significantly increased forward diffusion of Na+ and backdiffusion of H+. Both solutions also caused significant efflux of membrane… CONTINUE READING