Corpus ID: 14537110

Lysis of tumor cells by natural killer cells in mice is impeded by platelets.

  title={Lysis of tumor cells by natural killer cells in mice is impeded by platelets.},
  author={B. Nieswandt and M. Hafner and B. Echtenacher and D. M{\"a}nnel},
  journal={Cancer research},
  volume={59 6},
  • B. Nieswandt, M. Hafner, +1 author D. Männel
  • Published 1999
  • Biology, Medicine
  • Cancer research
  • Natural killer (NK) cells provide effective antitumoral activity in the blood stream of mice, leading to reduced metastasis. There are, however, tumor cells that metastasize despite the presence of an intact NK system. The capability of tumor cells to induce platelet aggregation, on the other hand, correlates with their enhanced metastatic potential. A counteractive role of platelets for the NK function in metastasis has never been conceived. Here we demonstrate for the first time that… CONTINUE READING
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