Lysis of bystander target cells after triggering of human cytotoxic T lymphocytes

@article{Fleischer1986LysisOB,
  title={Lysis of bystander target cells after triggering of human cytotoxic T lymphocytes},
  author={Bernhard Fleischer},
  journal={European Journal of Immunology},
  year={1986},
  volume={16}
}
  • B. Fleischer
  • Published 1986
  • Biology, Medicine
  • European Journal of Immunology
Human cloned cytotoxic T lymphocytes (CTL) specific for class I HLA antigens were used to investigate whether triggering of CTL leads to killing of innocent bystander target cells. After triggering of CTL by their specific target cells, lysis of bystander targets was detected in a 7‐h cytotoxicity assay. Considerable differences were found in the susceptibility of various target cells to this type of lysis. Targets susceptible to this bystander lysis were also susceptible to lysis by CTL… 
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