Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.

@article{Yang1997LysisOH,
  title={Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.},
  author={Otto O Yang and Alexandra Tran and Spyros A. Kalams and R Paul Johnson and Margo R. Roberts and Bruce D. Walker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 21},
  pages={11478-83}
}
Increasing evidence suggests that HIV-1-specific cytotoxic T lymphocytes (CTLs) are a key host immune response to HIV-1 infection. Generation of CTL responses for prevention or therapy of HIV-1 infection has several intrinsic technical barriers such as antigen expression and presentation, the varying HLA restrictions between different individuals, and the potential for viral escape by sequence variation or surface molecule alteration on infected cells. A strategy to circumvent these limitations… CONTINUE READING
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