Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model.

@article{Matsuda2005LysisdeficientBT,
  title={Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model.},
  author={Takeaki Matsuda and Tracy A Freeman and David W. Hilbert and Michael Duff and M. G. F. Fuortes and Philip P. Stapleton and John M. Daly},
  journal={Surgery},
  year={2005},
  volume={137 6},
  pages={639-46}
}
BACKGROUND Lysis-deficient (LyD) bacteriophages (phages) kill bacteria without endotoxin (Et) release. This may minimize systemic cytokine responses and limit inflammation in bacterial sepsis. We determined the effects of t amber A3 T4 LyD and virulent wild-type (WT) phages on mouse bacterial peritonitis. METHODS Balb/c mice were injected with B40sul Escherichia coli, treated intraperitoneally with LyD, WT, or a beta-lactam antibiotic [latamoxef sodium (LMOX)], and followed for survival. We… CONTINUE READING

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