Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

@article{Spruessel2012LysinespecificD1,
  title={Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation},
  author={Annika Spruessel and Johannes Hubertus Schulte and Stefanie Weber and M Necke and Kathrin Haendschke and Theresa Thor and Kristian W Pajtler and Alexander Schramm and Katharina Koenig and Linda Diehl and Pieter Mestdagh and Joke Vandesompele and Frank Speleman and Holger Jastrow and Lukas Heukamp and Roland Sch{\"u}le and Ullrich D{\"u}hrsen and Reinhard Buettner and Angelika Eggert and Joachim R G{\"o}thert},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={2039-2051}
}
Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a potential therapeutic target in solid cancers and more recently in acute myeloid leukemia. However, the potential side effects of a LSD1-inhibitory therapy remain elusive. Here, we show, with a newly established conditional in vivo knockdown model, that LSD1 represents a central regulator of hematopoietic stem and progenitor cells. LSD1 knockdown (LSD1-kd) expanded progenitor numbers by enhancing their proliferative… CONTINUE READING