Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.

  title={Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.},
  author={Dongmei Zhu and Stefanie H{\"o}lz and Eric Metzger and Mihael Pavlovic and Anett Jandausch and Cordula Jilg and Petra Galg{\'o}czy and Corinna Herz and Markus Moser and Daniel Metzger and Thomas G{\"u}nther and Sebastian J Arnold and Roland Sch{\"u}le},
  journal={Nature communications},
Propagation and differentiation of stem cell populations are tightly regulated to provide sufficient cell numbers for tissue formation while maintaining the stem cell pool. Embryonic parts of the mammalian placenta are generated from differentiating trophoblast stem cells (TSCs) invading the maternal decidua. Here we demonstrate that lysine-specific demethylase 1 (Lsd1) regulates differentiation onset of TSCs. Deletion of Lsd1 in mice results in the reduction of TSC number, diminished formation… CONTINUE READING
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