Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors.

@article{Schildhaus2011LysinespecificD1,
  title={Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors.},
  author={Hans-Ulrich Schildhaus and Raffael Riegel and Wolfgang Hartmann and Susanne Steiner and Eva Wardelmann and Sabine Merkelbach-Bruse and Shinya Tanaka and Hiroshi Sonobe and Roland Sch{\"u}le and Reinhard Buettner and Jutta Kirfel},
  journal={Human pathology},
  year={2011},
  volume={42 11},
  pages={1667-75}
}
Epigenetic changes including histone methylation, histone acetylation, and DNA methylation are thought to play important roles in the onset and progression of cancer in numerous tumor types. Recent evidence shows that dysregulated epigenetic modifications are as significant as genetic mutations and can act as oncogenic driver lesions causing autonomous growth of cancer cells. Here, we investigated the role of lysine-specific demethylase 1 in mesenchymal tumors. Lysine-specific demethylase 1 is… CONTINUE READING
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